{"id":6325,"date":"2025-07-22T09:24:32","date_gmt":"2025-07-22T00:24:32","guid":{"rendered":"https:\/\/www.tsukuba-psychiatry.com\/?p=6325"},"modified":"2025-07-22T09:24:32","modified_gmt":"2025-07-22T00:24:32","slug":"%e8%ab%96%e6%96%87%e3%81%8calzheimers-dementia%e3%81%ab%e6%8e%b2%e8%bc%89%e3%81%95%e3%82%8c%e3%81%be%e3%81%97%e3%81%9f","status":"publish","type":"post","link":"http:\/\/www.tsukuba-psychiatry.com\/?p=6325","title":{"rendered":"\u8ad6\u6587\u304cAlzheimer&#8217;s &amp; Dementia\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f"},"content":{"rendered":"\n<div>\u6e21\u8fba\u4eae\u5e73\u5148\u751f\u304c\u30da\u30f3\u30b7\u30eb\u30d9\u30cb\u30a2\u5927\u5b66\u3067\u307e\u3068\u3081\u305f Vacuolar Tauopathy\u306b\u95a2\u3059\u308b\u81e8\u5e8a\u75c5\u7406\u30b1\u30fc\u30b9\u30b7\u30ea\u30fc\u30ba\u306e\u8ad6\u6587\u304c\u3001<wbr \/>Alzheimer&#8217;s &amp; Dementia\u8a8c\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/div>\n<div>\u00a0<\/div>\n<div>Clinicopathological characterization of vacuolar tauopathy associated with VCP D395G<\/div>\n<div>Ryohei Watanabe, John D. Papatriantafyllou, Kengo Maeda, Geoffrey K. Aguirre, Masahiro Ando, Bernice Benoit, Murray Grossman, David J. Irwin, Boram Kim, Lauren Massimo, Corey T. McMillan, Sokratis G. Papageorgiou, Jeffrey S. Phillips, Tomoyuki Shiraishi, Yoshiko Sugihara, EunRan Suh, Hiroshi Takashima, Camilo Toro, Vivianna M. Van Deerlin, Ilya M. Nasrallah, Edward B. Lee.\u00a0<\/div>\n<div>Alzheimer&#8217;s &amp; DementiaVolume 21, Issue 7 e70427<\/div>\n<div><a href=\"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.70427\" target=\"_blank\" rel=\"noopener\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.70427&amp;source=gmail&amp;ust=1753229687731000&amp;usg=AOvVaw3PViOpeCoy5GRGIrw5OOXO\">https:\/\/alz-journals.<wbr \/>onlinelibrary.wiley.com\/doi\/<wbr \/>10.1002\/alz.70427<\/a><\/div>\n<div>\u00a0<\/div>\n<div>\u672c\u8ad6\u6587\u3067\u306f\u3001VCP \u907a\u4f1d\u5b50\u5185\u306e\u5909\u7570\u306b\u3088\u308a\u30bf\u30a6\u86cb\u767d\u8cea\u304c\u795e\u7d4c\u7d30\u80de\u5185\u306b\u84c4\u7a4d\u3059\u308b Vacuolar Tauopathy\uff08VT\uff09\u306b\u3064\u3044\u3066\u3001\u7c73\u56fd\u30fb\u30ae\u30ea\u30b7\u30e3\u30fb<wbr \/>\u65e5\u672c\u3067\u78ba\u8a8d\u3055\u308c\u305f5\u75c7\u4f8b\u3092\u5bfe\u8c61\u306b\u3001\u81e8\u5e8a\u75c7\u72b6\u3001\u8133\u753b\u50cf\u6240\u898b\u3001<wbr \/>\u795e\u7d4c\u75c5\u7406\u6240\u898b\u3092\u691c\u8a0e\u3057\u307e\u3057\u305f\u3002VCP \u306f\u30bf\u30a6\u306e\u4ee3\u8b1d\u30fb\u5206\u89e3\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304b\u3089\u3001<wbr \/>\u672c\u75be\u60a3\u306e\u75c5\u614b\u89e3\u660e\u306f\u795e\u7d4c\u5909\u6027\u306e\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u7406\u89e3\u306b\u8cc7\u3059\u308b\u3082\u306e<wbr \/>\u3068\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/div>\n<div>\u672c\u7814\u7a76\u306b\u3088\u308a\u3001VT \u306e\u81e8\u5e8a\u8868\u73fe\u578b\u306f\u884c\u52d5\u578b\u524d\u982d\u5074\u982d\u578b\u8a8d\u77e5\u75c7\uff08bvFTD\uff09<wbr \/>\u3092\u57fa\u76e4\u3068\u3057\u3064\u3064\u3001\u539f\u767a\u6027\u9032\u884c\u6027\u5931\u8a9e\uff08PPA\uff09<wbr \/>\u306e\u8a3a\u65ad\u57fa\u6e96\u3092\u90e8\u5206\u7684\u306b\u6e80\u305f\u3059\u591a\u69d8\u306a\u8a00\u8a9e\u75c7\u72b6\u3092\u793a\u3057\u3001<wbr \/>\u3082\u3057\u304f\u306f\u75c5\u521d\u671f\u304b\u3089\u306e\u8996\u7a7a\u9593\u8a8d\u77e5\u969c\u5bb3\u3084\u8a18\u61b6\u969c\u5bb3\u3092\u4f34\u3046\u306a\u3069\u3001<wbr \/>\u975e\u5b9a\u578b\u7684\u306a\u3082\u306e\u3067\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u307e\u305f\u3001<wbr \/>\u62e1\u6563\u5f37\u8abfMRI\u3067\u306f\u5927\u8133\u65b0\u76ae\u8cea\u306b\u7279\u5fb4\u7684\u306a \u201cribboning\u201d \u304c\u8a8d\u3081\u3089\u308c\u3001<wbr \/>\u540c\u9818\u57df\u306e\u7a7a\u80de\u6027\u75c5\u5909\u3092\u53cd\u6620\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002<wbr \/>\u52a0\u3048\u3066\u3001\u75c5\u5909\u90e8\u306e\u795e\u7d4c\u7d30\u80de\u5185\u306b\u306f Alzheimer\u75c5\u69d8\u306e\u795e\u7d4c\u539f\u7dda\u7dad\u5909\u5316\uff08NFT\uff09<wbr \/>\u306e\u4ed6\u306b\u5186\u5f62\u3067\u7dfb\u5bc6\u306a\u69cb\u9020\u3092\u3082\u3064\u5c01\u5165\u4f53\u304c\u6df7\u5728\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u308a<wbr \/>\u307e\u3057\u305f\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u00a0<\/div>\n<p>\u306a\u304a\u3001<wbr \/>\u4e0a\u8a18\u8ad6\u6587\u3067\u5831\u544a\u3057\u305f\u75c7\u4f8b\u306e\u6b7b\u5f8c\u8133\u304b\u3089\u62bd\u51fa\u3055\u308c\u305f\u30bf\u30a6\u7dda\u7dad\u306e\u30b3\u30a2\u8d85<wbr \/>\u5fae\u7d30\u69cb\u9020\u3092\u3001\u4ee5\u4e0b\u3067\u516c\u958b\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<div>Repositioning of polyubiquitin alters the pathologic tau filament structure<\/div>\n<div>Ryohei Watanabe, Benjamin C. Creekmore, Nabil F. Darwich, Hong Xu, Lakshmi Changolkar, Kevt\u2019her Hoxha, Bin Zhang, Caroline M. O\u2019Rourke, George M. Burslem, Virginia M.-Y. Lee, Yi-Wei Chang, Edward B. Lee<br \/>bioRxiv 2025.05.02.651930<br \/>doi:\u00a0<a href=\"https:\/\/doi.org\/10.1101\/2025.05.02.651930\" target=\"_blank\" rel=\"noopener\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/doi.org\/10.1101\/2025.05.02.651930&amp;source=gmail&amp;ust=1753229687731000&amp;usg=AOvVaw1A0oASF276L9ZIrHU_WSce\">https:\/\/doi.org\/10.1101\/2025.<wbr \/>05.02.651930<\/a><\/div>\n\n\n","protected":false},"excerpt":{"rendered":"<p>\u6e21\u8fba\u4eae\u5e73\u5148\u751f\u304c\u30da\u30f3\u30b7\u30eb\u30d9\u30cb\u30a2\u5927\u5b66\u3067\u307e\u3068\u3081\u305f Vacuolar Tauopathy &hellip; <\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[127,17],"tags":[],"_links":{"self":[{"href":"http:\/\/www.tsukuba-psychiatry.com\/index.php?rest_route=\/wp\/v2\/posts\/6325"}],"collection":[{"href":"http:\/\/www.tsukuba-psychiatry.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.tsukuba-psychiatry.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.tsukuba-psychiatry.com\/index.php?rest_route=\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"http:\/\/www.tsukuba-psychiatry.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=6325"}],"version-history":[{"count":1,"href":"http:\/\/www.tsukuba-psychiatry.com\/index.php?rest_route=\/wp\/v2\/posts\/6325\/revisions"}],"predecessor-version":[{"id":6326,"href":"http:\/\/www.tsukuba-psychiatry.com\/index.php?rest_route=\/wp\/v2\/posts\/6325\/revisions\/6326"}],"wp:attachment":[{"href":"http:\/\/www.tsukuba-psychiatry.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=6325"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.tsukuba-psychiatry.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=6325"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.tsukuba-psychiatry.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=6325"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}