{"id":6817,"date":"2026-09-04T09:26:42","date_gmt":"2026-09-04T00:26:42","guid":{"rendered":"https:\/\/www.tsukuba-psychiatry.com\/?p=6817"},"modified":"2026-09-04T09:26:42","modified_gmt":"2026-09-04T00:26:42","slug":"%e8%ab%96%e6%96%87%e3%81%8cnature-structural-molecular-biology%e3%81%ab%e6%8e%b2%e8%bc%89%e3%81%95%e3%82%8c%e3%81%be%e3%81%97%e3%81%9f","status":"publish","type":"post","link":"https:\/\/www.tsukuba-psychiatry.com\/?p=6817","title":{"rendered":"\u8ad6\u6587\u304cNature Structural &amp; Molecular Biology\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f"},"content":{"rendered":"\n<p>\u6e21\u8fba\u4eae\u5e73\u5148\u751f\u304c\u30da\u30f3\u30b7\u30eb\u30d9\u30cb\u30a2\u5927\u5b66\u3067\u884c\u3063\u305f\u3001Vacuolar Tauopathy\uff08VT\uff09\u304a\u3088\u3073Alzheimer disease\uff08AD\uff09\u306e\u60a3\u8005\u8133\u7531\u6765\u30bf\u30a6\u7dda\u7dad\u306b\u95a2\u3059\u308b\u7814\u7a76\u6210\u679c\u304c\u3001Nature Structural &amp; Molecular Biology\u8a8c\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>Repositioning of polyubiquitin alters the pathologic tau filament structure<\/p>\n<p>Ryohei Watanabe, Benjamin C. Creekmore, Nabil F. Darwich, Courtney L. Smith, Hong Xu, Angelina Baltazar, Sacha Salphati, Lakshmi Changolkar, Kevt\u2019her Hoxha, Bin Zhang, Caroline M. O\u2019Rourke, George M. Burslem, Virginia M.-Y. Lee, Yi-Wei Chang, Edward B. Lee<\/p>\n<p>Nature Structural &amp; Molecular Biology<br \/>https:\/\/www.nature.com\/articles\/s41594-026-01879-4<\/p>\n<p>\u672c\u8ad6\u6587\u3067\u306f\u3001AD\u304a\u3088\u3073VT\u306e\u60a3\u8005\u8133\u304b\u3089\u62bd\u51fa\u3057\u305f\u30bf\u30a6\u7dda\u7dad\u306b\u3064\u3044\u3066\u3001\u30de\u30a6\u30b9\u8133\u3078\u306e\u63a5\u7a2e\u5b9f\u9a13\u3068\u30af\u30e9\u30a4\u30aa\u96fb\u5b50\u9855\u5fae\u93e1\uff08cryo-EM\uff09\u306b\u3088\u308b\u69cb\u9020\u89e3\u6790\u3092\u884c\u3044\u307e\u3057\u305f\u3002AD\u30bf\u30a6\u3068VT\u30bf\u30a6\u3067\u306f\u3001\u30de\u30a6\u30b9\u8133\u5185\u306b\u5f62\u6210\u3055\u308c\u308b\u30bf\u30a6\u75c5\u7406\u306e\u5206\u5e03\u3084\u5f62\u614b\u306b\u7570\u306a\u308b\u7279\u5fb4\u304c\u307f\u3089\u308c\u307e\u3057\u305f\u3002\u307e\u305f\u3001VT\u60a3\u8005\u8133\u3067\u306f\u8907\u6570\u306e\u7570\u306a\u308b\u30bf\u30a6\u7dda\u7dad\u69cb\u9020\u304c\u8a8d\u3081\u3089\u308c\u3001\u305d\u308c\u305e\u308c\u3067\u7dda\u7dad\u3092\u69cb\u6210\u3059\u308b\u30d7\u30ed\u30c8\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u9593\u306e\u7d50\u5408\u69d8\u5f0f\u304c\u7570\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n<p>\u3055\u3089\u306b\u3001\u30bf\u30a6\u7dda\u7dad\u306b\u4ed8\u52a0\u3055\u308c\u305f\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u306b\u7740\u76ee\u3057\u3001\u30dd\u30ea\u30e6\u30d3\u30ad\u30c1\u30f3\u306b\u7d50\u5408\u3059\u308b\u5316\u5408\u7269\u3067\u3042\u308bubistatin B\u3092\u7dda\u7dad\u306b\u53cd\u5fdc\u3055\u305b\u305f\u5f8c\u306b\u69cb\u9020\u89e3\u6790\u3057\u305f\u3068\u3053\u308d\u3001\u4e00\u90e8\u306eVT\u30bf\u30a6\u7dda\u7dad\u3067\u306f\u3001\u7dda\u7dad\u30b3\u30a2\u5468\u56f2\u306e\u96fb\u5b50\u5bc6\u5ea6\u306e\u5206\u5e03\u304a\u3088\u3073\u30d7\u30ed\u30c8\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u9593\u306e\u754c\u9762\u69cb\u9020\u306b\u5909\u5316\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u304b\u3089\u3001\u30bf\u30a6\u7dda\u7dad\u306e\u69cb\u9020\u306f\u3001\u7dda\u7dad\u4e0a\u306b\u5b58\u5728\u3059\u308b\u7ffb\u8a33\u5f8c\u4fee\u98fe\u306b\u3088\u3063\u3066\u5f71\u97ff\u3092\u53d7\u3051\u308b\u53ef\u80fd\u6027\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u306a\u304a\u3001\u672c\u7814\u7a76\u306b\u7528\u3044\u305fVT\u75c7\u4f8b\u306e\u81e8\u5e8a\u30fb\u75c5\u7406\u5b66\u7684\u7279\u5fb4\u3092\u4e0b\u8a18\u3067\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002\u4eca\u56de\u306e\u7814\u7a76\u306f\u3001\u3053\u308c\u3089\u306e\u60a3\u8005\u8133\u306b\u84c4\u7a4d\u3057\u305f\u30bf\u30a6\u7dda\u7dad\u3092\u3001\u5206\u5b50\u69cb\u9020\u306e\u30ec\u30d9\u30eb\u3067\u3055\u3089\u306b\u89e3\u6790\u3057\u305f\u3082\u306e\u3067\u3059\u3002<\/p>\n<p>Clinicopathological characterization of vacuolar tauopathy associated with VCP D395G<\/p>\n<p>Watanabe R, Papatriantafyllou JD, Maeda K, et al.<\/p>\n<p>Alzheimer\u2019s &amp; Dementia 21, e70427 (2025)<br \/>https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full\/10.1002\/alz.70427<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6e21\u8fba\u4eae\u5e73\u5148\u751f\u304c\u30da\u30f3\u30b7\u30eb\u30d9\u30cb\u30a2\u5927\u5b66\u3067\u884c\u3063\u305f\u3001Vacuolar Tauopathy\uff08 [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[128,17,117],"tags":[],"_links":{"self":[{"href":"https:\/\/www.tsukuba-psychiatry.com\/index.php?rest_route=\/wp\/v2\/posts\/6817"}],"collection":[{"href":"https:\/\/www.tsukuba-psychiatry.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tsukuba-psychiatry.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tsukuba-psychiatry.com\/index.php?rest_route=\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tsukuba-psychiatry.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=6817"}],"version-history":[{"count":1,"href":"https:\/\/www.tsukuba-psychiatry.com\/index.php?rest_route=\/wp\/v2\/posts\/6817\/revisions"}],"predecessor-version":[{"id":6818,"href":"https:\/\/www.tsukuba-psychiatry.com\/index.php?rest_route=\/wp\/v2\/posts\/6817\/revisions\/6818"}],"wp:attachment":[{"href":"https:\/\/www.tsukuba-psychiatry.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=6817"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tsukuba-psychiatry.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=6817"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tsukuba-psychiatry.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=6817"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}